Histologic/histochemical grading system for osteoarthritic articular cartilage. Reproducibility and validity

Validity of histopathological grading of articular cartilage from osteoarthritic knee joints.

OBJECTIVES To determine the validity of the histological-histochemical grading system (HHGS) for osteoarthritic (OA) articular cartilage. METHODS Human articular cartilage was obtained from macroscopically normal (n = 13) and OA (n = 21) knee joints. Sections of central and peripheral regions of normal samples were produced. Sections of regions containing severe, moderate, and mild OA changes...

Chondrocyte multiplication in osteoarthritic articular cartilage.

Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage

Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.   Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied.   Methods: Using immunohistochemistry and standard we...

Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.

PURPOSE To determine whether articular chondrocytes derived from osteoarthritic knee joints could evoke alloreactive proliferation of peripheral blood mononuclear cells (PBMC) and inhibit mitogenic activity of polyclonally activated CD4+ major histocompatibility complex (MHC) class II- restricted T cells in vitro. METHODS Osteoarthritic cartilages of 17 patients aged 61 to 85 years were harve...

Ultrastructure of chondrocytes in osteoarthritic femoral articular cartilage.

BACKGROUND Osteoarthritis (OA) is a common problem in elderly, but it is not an inevitable feature of ageing. About 80-90% of individuals of both sexes have radiographic evidence of OA by the time they reach an age of 65. But not all of them have the symptoms like pain and decreased joint motion. OBJECTIVE The objective of the present study was conducted to find out whether the osteoarthritic...